We have just taken delivery of a new Waters TQ-XS Triple Quadrupole Mass Spectrometer, coupled to an ACQUITY UPLC System with 2D LC Technology. The Weqas Reference Laboratory is the first clinical laboratory to have this Waters flagship instrument in the UK. Such an exciting acquisition will enable the Reference Laboratory to offer additional Reference Measurement Services in our bid to support global initiative for metrological traceability. Initial work will focus on transferring our steroid methods from the current ID-GCMS method onto this platform. With the increased instrument sensitivity we are hoping to be in a position to offer Reference Measurement values for all our endocrine samples for cortisol, testosterone, progesterone and oestradiol. Further work will then focus on developing a Reference Method for vitamin D, utilising the 2D capabilities of the LC system.