GCMS – Bile Acids
GCMS – Bile Acids
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Current immunoassays for Bile acids measure the total bile acids present. Monitoring each of the individual major bile acids will enable the significant biases and differences observed between each of the methods to be addressed
Traceability - Serum/Plasma
| Measurand | Standard (certfied purity) | Control Material |
|---|---|---|
| Cholic Acid | Sigma >99% | "In house" |
| Deoxycholic Acid | Sigma >99% | "In house" |
| Chenodeoxycholic Acid | Sigma >99% | "In house" |
Measurement Method Details
| Measurand / Internal Standard | Sample pre-treatment | Derivative |
|---|---|---|
Cholic Acid | Solid phase extraction Gel Chromatography | Silyl methyl ether |
| Deoxycholic acid [2,2,4,4,-d4]-deoxycholic acid | Solid phase extraction Gel Chromatography | Silyl methyl ether |
| Chenodeoxycholic acid [2,2,4,4,-d4]-chenodeoxycholic acid | Solid phase extraction Gel Chromatography | Silyl methyl ether |
Accreditation
